Oedema Study : Chroedem
Assessment of Tissue and Biomolecular Complements of Lower Limb Chronic Oedema
University Hospital, Montpellier
60 participants
Jan 3, 2017
OBSERVATIONAL
Conditions
Summary
The chroedem study is aiming to assess tissue and biomolecular components of chronic lower limb oedema (CO). The investigators working hypothesis is that according to the aetiology of CO, the proportion of oedema \& composition of peri-oedema tissues (fat, muscle, fibrosis/inflammation) might differ and could at least in part explain differences in failure/success of compressive therapies from one patient to another. For that purpose, 24 patients with a post-thrombotic syndrome (PTS)-related oedema and 24 patients with a primary lymphedema will undergo a magnetic resonance imaging (MRI)) of the legs and biological (genetic) testing.
Eligibility
Inclusion Criteria1
- Lower limb CO secondary to PTS or Primary lymphoedema (We will include secondary lymphedema of the lower limbs only if the matcing constraints on age and length of evolution do not allow pairing)
Exclusion Criteria9
- Bilateral CO
- Obesity
- Mixed CO (PTS and lymphatic origins)
- CO of other origin : Heart failure, hepatic or renal impairment
- Denutrition
- Contra-indication to MRI
- Patient not affiliated to French Health Insurance System
- Patient protected by the law
- Patient refusing to participate
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Locations(3)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT02914808