RecruitingNot ApplicableNCT02916810

Alternative Stimulation Mode and Location for Auditory Hallucination Neuromodulation Treatment


Sponsor

The University of Texas Health Science Center, Houston

Enrollment

140 participants

Start Date

Feb 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of the study is to test the hypothesis that functionally navigated repetitive TMS stimulations to the prefrontal cortex (PFC) modulate aberrant cortical electrical activities at PFC circuitry. The TMS location of the PFC site will be individually localized by the symptom-related functional connectivity between PFC and symptom related areas (such as the auditory and language processing cortex). The investigators predict that such modulation will correct abnormal activities in patients with schizophrenia, reduce symptoms, especially auditory hallucination, and improve working memory/sustained attention performance.


Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study tests new ways of delivering brain stimulation (using magnetic pulses) to reduce or eliminate auditory hallucinations — hearing voices or sounds that aren't there — in people with schizophrenia who still experience hallucinations despite medication. **You may be eligible if...** - You are between 18 and 50 years old - You have been diagnosed with a schizophrenia-spectrum disorder - You still hear voices or have auditory hallucinations despite trying at least two different antipsychotic medications - You are currently under the care of a licensed mental health provider **You may NOT be eligible if...** - Your hallucinations are well-controlled by medication - You have certain metal implants in your head or body that are unsafe with magnetic stimulation - You have a history of seizures (unless already evaluated) - You are not currently receiving mental health care This study offers hope for patients whose voices are not controlled by medication alone. Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEActive rTMS stimulation

Participants will receive two rTMS sessions in each treatment visit for up to 22 visits within about 6 weeks. There is a 30-minute rest between the two rTMS sessions.

DEVICESham rTMS stimulation

Participants will receive two sham rTMS sessions in each treatment visit for up to 22 visits within about 6 weeks. There is a 30-minute rest between the two sham rTMS sessions.


Locations(1)

The University of Texas Health Science Center at Houston

Houston, Texas, United States

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NCT02916810


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