Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy

This study asks whether women with breast cancer who respond completely to pre-surgery drug treatment (neoadjuvant therapy) — meaning no cancer can be found on biopsy — can safely skip surgery (lumpectomy) and/or radiation, avoiding the side effects of these procedures. **You may be eligible if...** - You have been diagnosed with invasive breast cancer (stage T1 or T2, meaning tumor 5 cm or smaller) - Your cancer has not spread to distant organs - You are being treated with standard neoadjuvant (pre-surgery) drug therapy - You are being treated at MD Anderson Cancer Center or a participating site **You may NOT be eligible if...** - You have inflammatory breast cancer (a rare, aggressive form) - Your cancer has spread to distant organs - You have already had radiation to the chest area - You are pregnant For women who achieve a complete response to drug treatment, avoiding surgery and radiation could maintain quality of life without compromising survival. Talk to your doctor to see if this trial is right for you.