RecruitingNot ApplicableNCT02958462

Pre-myeloid Cancer and Bone Marrow Failure Clinic Study


Sponsor

Mayo Clinic

Enrollment

2,000 participants

Start Date

Jan 16, 2017

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial tests next generation sequencing (NGS) for the detection of precursor features of pre-myeloid cancers and bone marrow failure syndromes. NGS is a procedure that looks at relevant cancer associated genes and what they do. Finding genetic markers for pre-malignant conditions may help identify patients who are at risk of pre-myeloid cancers and bone marrow failure syndromes and lead to earlier intervention.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study follows patients who have — or are at risk for — pre-cancerous blood and bone marrow conditions. These include rare disorders where blood cells are abnormal but have not yet become full cancer. Researchers hope to learn more about how these conditions develop and how to catch them earlier. You may be eligible if: - You have been diagnosed with ICUS, CHIP, CCUS, low-risk MDS, or a bone marrow failure syndrome - You have an inherited genetic syndrome that raises cancer risk (such as GATA2 or RUNX1 mutations) - You are a family member of someone with one of these conditions - You are suspected to be at high risk for developing one of these conditions - You are 18 years of age or older You may NOT be eligible if: - You are under 18 years of age Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREBiospecimen Collection

Undergo blood sample, hair follicle, and saliva collection

PROCEDUREBone Marrow Biopsy

Undergo a bone marrow biopsy

PROCEDUREPunch Biopsy

Undergo a skin punch biopsy

PROCEDUREBuccal Swab

Undergo a saliva or buccal swab

OTHERClinical Evaluation

Undergo clinical assessment

OTHERGenetic Counseling

Receive genetic counseling

OTHERQuality-of-Life Assessment

Ancillary studies

OTHERElectronic Health Record Review

Ancillary studies


Locations(3)

Mayo Clinic in Arizona

Scottsdale, Arizona, United States

Mayo Clinic in Florida

Jacksonville, Florida, United States

Mayo Clinic in Rochester

Rochester, Minnesota, United States

View Full Details on ClinicalTrials.gov

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NCT02958462


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