RecruitingEarly Phase 1NCT02973633

Diffusion MRI in Heart Failure

Sponsor

Massachusetts General Hospital

Enrollment

160 participants

Start Date

Jun 30, 2017

Study Type

INTERVENTIONAL

Conditions

Heart Failure Myocardial Infarction Left Ventricular Hypertrophy

Summary

The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood. The investigators hypothesize that imaging the diffusion of water in the heart with MRI will allow its microstructure to be resolved. The investigators further hypothesize that the characterization of microstructural changes in the heart will help elucidate the pathogenesis of heart failure and the transition from a compensated to a decompensated state. Patients with recent myocardial infarcts and left ventricular hypertrophy, who are at risk for the development of heart failure, will be enrolled. The participants will undergo serial diffusion tensor MRI (DTI) imaging of the heart to characterize changes in myocardial microstructure over time.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is using a special type of MRI scan called diffusion MRI to look at the structure of heart muscle in patients who have had a heart attack or have heart failure, compared to healthy adults. **You may be eligible if...** - You are a healthy adult with no history of high blood pressure, diabetes, or heart disease (as a comparison participant), OR - You had a heart attack (specifically an ST-elevation MI) in the last 6–10 weeks, are now free of chest pain, and have seen a heart specialist since leaving the hospital, OR - You have had a heart failure episode in the past 12 months and have an enlarged heart (left ventricular hypertrophy) confirmed by scan **You may NOT be eligible if...** - You have metal objects or implants in your body (like shrapnel or certain surgical clips) - You have a pacemaker, defibrillator, or certain other medical devices - You have severe claustrophobia (fear of enclosed spaces) - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEDiffusion Tensor MRI (DTI)

Diffusion Tensor MRI (DTI) measures the diffusion of water in the heart, which allows the orientation of the muscle fibers in the heart to be determined.

DRUGGadolinium DOTA Meglumine

Late Gadolinium enhancement