RecruitingNot ApplicableNCT02984761

Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy

CSP #2005 - Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy Trial (VALOR)


Sponsor

VA Office of Research and Development

Enrollment

670 participants

Start Date

Apr 13, 2017

Study Type

INTERVENTIONAL

Conditions

Summary

Patients with stage I non-small cell lung cancer have been historically treated with surgery whenever they are fit for an operation. However, an alternative treatment known as stereotactic radiotherapy now appears to offer an equally effective alternative. Doctors believe both are good treatments and are therefore conducting this study to determine if one may be possibly better than the other.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two treatments for early-stage lung cancer in veterans: surgery to remove the tumor versus a focused, high-dose radiation treatment called stereotactic body radiation therapy (SBRT), to find out which works better. **You may be eligible if...** - You are 18 or older - You have been diagnosed with (or are highly suspected of having) stage I non-small cell lung cancer (NSCLC), the most common type of lung cancer - Your tumor is 5 cm or smaller - Your overall health and functioning is reasonably good (Karnofsky score 70 or higher) - You are willing to be randomly assigned to either surgery or radiation **You may NOT be eligible if...** - Your cancer has spread beyond the lung (stage II or higher) - Your tumor is too large or in a location that makes local treatment not feasible - You are not healthy enough to safely undergo either surgery or radiation - You decline random assignment to a treatment group Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONStereotactic Radiotherapy

Stereotactic radiotherapy uses high doses of ionizing energy to treat cancer cells with image guidance. The treatment is delivered in an outpatient setting, and for purposes of this trial is delivered in 3-5 fractions.

PROCEDUREAnatomic Pulmonary Resection

An anatomic pulmonary resection is an oncologic procedure that dissects out an anatomically defined segment of the lung to remove all of the lung tissue around a lung tumor. It requires an operation with general anesthesia, with a short hospital stay. The procedure entails removal of lymph nodes inside the chest that might not be easily accessible without an operation.


Locations(17)

VA Long Beach Healthcare System, Long Beach, CA

Long Beach, California, United States

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

West Los Angeles, California, United States

Bay Pines VA Healthcare System, Pay Pines, FL

Bay Pines, Florida, United States

Miami VA Healthcare System, Miami, FL

Miami, Florida, United States

Edward Hines Jr. VA Hospital, Hines, IL

Hines, Illinois, United States

Richard L. Roudebush VA Medical Center, Indianapolis, IN

Indianapolis, Indiana, United States

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

Baltimore, Maryland, United States

VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Boston, Massachusetts, United States

VA Ann Arbor Healthcare System, Ann Arbor, MI

Ann Arbor, Michigan, United States

Minneapolis VA Health Care System, Minneapolis, MN

Minneapolis, Minnesota, United States

Durham VA Medical Center, Durham, NC

Durham, North Carolina, United States

Louis Stokes VA Medical Center, Cleveland, OH

Cleveland, Ohio, United States

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

Philadelphia, Pennsylvania, United States

VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

Pittsburgh, Pennsylvania, United States

Michael E. DeBakey VA Medical Center, Houston, TX

Houston, Texas, United States

Hunter Holmes McGuire VA Medical Center, Richmond, VA

Richmond, Virginia, United States

Clement J. Zablocki VA Medical Center, Milwaukee, WI

Milwaukee, Wisconsin, United States

View Full Details on ClinicalTrials.gov

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NCT02984761


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