Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

This study collects skin biopsy samples from patients who have signs of vasculitis — inflammation of blood vessels — in their skin. Researchers use advanced genetic analysis (transcriptomics) to study which genes are active in the affected tissue, with the goal of better understanding different types of vasculitis and improving diagnosis. You may be eligible if: - You have a skin lesion (such as purple spots, raised purplish marks, nodules, ulcers, or hive-like lesions) believed to be caused by active vasculitis - You have a suspected or confirmed diagnosis of a form of vasculitis (e.g., IgA vasculitis, granulomatosis with polyangiitis, microscopic polyangiitis, polyarteritis nodosa, cryoglobulinemic vasculitis, or others) - You are 5 years of age or older - You are willing and able to provide informed consent (or assent for minors) You may NOT be eligible if: - You are younger than 5 years old - You are not a good candidate for a skin biopsy, or the risks of biopsy outweigh the benefits - You have very low blood counts (low white cells, platelets, or hemoglobin) - You have an active infection at or near the biopsy site, poor circulation, or other conditions that increase biopsy risk - You are pregnant or nursing - You are unable to provide informed consent Talk to your doctor to see if this trial is right for you.