RecruitingPhase 3NCT03011684

Fertility Preservation Using Tamoxifen and Letrozole in Estrogen Sensitive Tumors Trial

Sponsor

University of California, San Francisco

Enrollment

309 participants

Start Date

Jul 21, 2016

Study Type

INTERVENTIONAL

Conditions

Infertility

Summary

Latrogenic infertility as a result of cancer treatment has a profound effect on long-term quality of life in survivors of reproductive-age cancers. Oocyte cryopreservation prior to cancer treatment has been associated with improved quality of life, with a potential ability to reduce long-term decision-related regret in cancer survivors. Though letrozole plus gonadotropin and and tamoxifen plus gonadotropin are currently routinely used worldwide in ovarian stimulation cycles for fertility preservation in patients with estrogen-receptor-positive breast cancer, it is not clear which of the two might lead to improved oocyte yield. Improved knowledge about the efficacy of these medications, with regard to oocyte yield, has the potential to significantly improve quality of life in reproductive-age breast cancer survivors.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is testing two drugs — tamoxifen and letrozole — used together to safely stimulate egg production (ovarian stimulation) in women with newly diagnosed breast cancer who want to freeze their eggs before starting chemotherapy, in order to preserve their fertility. **You may be eligible if...** - You have been newly diagnosed with breast cancer and have not yet started chemotherapy - You want to freeze your eggs before cancer treatment begins - You are 18 years of age or older **You may NOT be eligible if...** - You have already started or completed chemotherapy - You have had a previous breast cancer diagnosis that required chemotherapy - Your breast cancer is Stage IV (meaning it has spread to other parts of the body) - Your oncologist advises against participating in this trial Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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