Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal Melting
Corneal Collagen Crosslinking to Increase the Resistance of the Graft Used as a Support for the Boston Keratoprosthesis Type I Against Corneal Melting
Centre hospitalier de l'Université de Montréal (CHUM)
40 participants
Jan 4, 2017
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to demonstrate the safety and efficacy of the corneal collagen crosslinking with riboflavin and ultraviolet A in aim to increase the resistance of the graft used as a support for the Boston keratoprosthesis (KPro) type I against corneal melting (keratolysis or sterile necrosis).
Eligibility
Inclusion Criteria3
- Candidate for KPro type I
- Capacity to give written consent
- Ability to be followed for the duration of the study
Exclusion Criteria9
- Participation in another interventional study
- Failure to wear a therapeutic contact lens due to abnormalities of the eyelids.
- Inability to give written consent
- Contraindications to the KPro type I:
- Severe dryness with keratinization of the ocular surface
- Intraocular tumor
- Terminal glaucoma
- Inoperable retinal detachment
- Phthisis bulbi
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Interventions
Corneal graft support for the KPro will be crosslinked and used with the standard surgical technique
Corneal graft-support will be de-epithelialized and soaked with riboflavin and then used with the standard surgical technique
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03041883