RecruitingNCT03054584

Genetic Basis of Melanocytic Nevi

Sponsor

University of California, Davis

Enrollment

50 participants

Start Date

Jun 26, 2017

Study Type

OBSERVATIONAL

Conditions

Melanocytic Nevi

Summary

The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens. Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples: 1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis. 2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates the genetic changes responsible for the development of moles (called melanocytic nevi) — clusters of pigmented cells on the skin — to better understand why they form, how they differ from person to person, and whether certain gene changes make some moles more likely to become melanoma (a type of skin cancer). **You may be eligible if...** - You are 18 years of age or older - You have one or more moles (melanocytic nevi) on your skin - You are willing to have a small skin sample collected for genetic analysis **You may NOT be eligible if...** - You are under 18 years old - You do not have any moles - You have a bleeding disorder (a condition where your blood does not clot normally) or you are taking blood-thinning medications (anticoagulants), which would make it unsafe to collect a tissue sample Talk to your doctor to see if this trial is right for you.

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Interventions

OTHERCollecting Nevi

Will be collecting Nevi and completing a DNA analysis, no intervention will be made.

Locations(1)

University of California-Davis, Department of Dermatology

Sacramento, California, United States

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NCT03054584

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