Combination of Ibuprofen, G-CSF and Plerixafor as Stem Cells Mobilization Regimen in Patients Affected by X-CGD

This study is testing a combination of three drugs — ibuprofen, G-CSF, and plerixafor — to mobilize stem cells from the bone marrow in men with X-linked chronic granulomatous disease (X-CGD), a rare immune deficiency. The goal is to collect enough stem cells to potentially use in gene therapy. You may be eligible if... - You have a confirmed genetic diagnosis of X-CGD - You are a male between 18 and 45 years old - You are in reasonably good health (Karnofsky Index above 80%) - You have normal heart, kidney, liver, and lung function - You have no history of blood clots and test negative for clotting disorders You may NOT be eligible if... - You have had a bone marrow transplant or gene therapy previously - You have used other experimental drugs recently or are currently on interferon-gamma therapy - You have active inflammatory bowel disease or a recent serious infection - You have cancer, a blood disorder, or a history of uncontrolled seizures or deep vein thrombosis - You have HIV, hepatitis C, hepatitis B, or active alcohol/substance abuse - You have a contraindication to any of the study drugs Talk to your doctor to see if this trial is right for you.