RecruitingNCT03059420
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
Sponsor
Boston Children's Hospital
Enrollment
20,000 participants
Start Date
Feb 1, 2004
Study Type
OBSERVATIONAL
Conditions
Facial PalsyCongenital Fibrosis of Extraocular MusclesDuane Retraction SyndromeDuane Radial Ray SyndromeMobius SyndromeBrown SyndromeMarcus Gunn SyndromeStrabismus CongenitalHorizontal Gaze PalsyHorizontal Gaze Palsy With Progressive ScoliosisFacial Paresis, Hereditary, CongenitalThird Nerve PalsyFourth Nerve PalsySixth Nerve PalsySynkinesisOcular Motility DisordersLevator-Medial Rectus SynkinesisAthabaskan Brainstem DysgenesisTongue ParalysisNinth Nerve DisorderFifth Nerve PalsySeventh Nerve PalsyEleventh Nerve DisorderTwelfth Nerve DisorderVagus Nerve ParalysisMoebius Sequence
Summary
The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.
Eligibility
Min Age: 1 Day
Inclusion Criteria1
- The Engle Lab is very interested in enrolling individuals with congenital conditions related to eye movement, cranial nerve and brainstem-based dysfunction, often broadly referred to as congenital cranial dysinnervation disorders (CCDDs).
Exclusion Criteria1
- Individuals with cranial nerve disorders associated with known disorders, such as Saethre-Chotzen associated with established genetic mutations, or acquired conditions including trauma, stroke, tumor or spinal cord injuries.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03059420