Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies

This genetic research study is investigating the causes of strabismus (misaligned eyes) and congenital cranial dysinnervation disorders (CCDDs) — a group of rare conditions where nerves controlling eye, face, and head movements don't develop properly. The Engle Lab at Boston Children's Hospital is collecting genetic samples to find the underlying gene mutations. You may be eligible if... - You were born with a condition affecting eye movement, cranial nerve function, or brainstem-related movement control - You have a congenital (present from birth) form of one of these conditions - You are at least 1 day old (all ages welcome) You may NOT be eligible if... - Your cranial nerve disorder is associated with a known genetic syndrome (such as Saethre-Chotzen syndrome) - Your condition was caused by an acquired event such as trauma, stroke, tumor, or spinal cord injury Talk to your doctor to see if this trial is right for you.