RecruitingPhase 4NCT03088852

Magnesium Deficiency In Patients Hospitalized in Internal Medicine Wards


Sponsor

Frieda Wolf

Enrollment

330 participants

Start Date

May 10, 2017

Study Type

INTERVENTIONAL

Conditions

Summary

Hypomagnesemia is a common entity in the inpatient and outpatient setting. in previous retrospective study hypomagnesemic patients have higher mortality and longer hospitalization. whether hypomagnesemia is merely a marker of poor prognosis, or whether replacing it can improve outcomes is unclear. The current standard of care is to discharge these patients without workup or further treatment, even if patients had received intravenous therapy while hospitalized. The investigator wish to examine prospectively whether giving replacement therapy affects mortality, length of hospital stay and overall well-being. In order to replete intracellular levels and replete magnesium stores, magnesium should be given for several months.


Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether giving magnesium supplements to hospitalized patients with low blood magnesium levels (hypomagnesemia) improves outcomes such as survival, length of hospital stay, and overall wellbeing, compared to the current standard of care which often involves no further treatment after discharge. Low magnesium is commonly found in hospitalized patients and has been associated with higher mortality, but whether correcting it makes a difference is unclear. Adults aged 18 or older admitted to an internal medicine ward with a magnesium level at or below 1.9 mg/dL who can provide consent are eligible, while those with advanced kidney disease, severe diarrhea, critically ill patients, or patients already receiving magnesium are excluded. Participants will receive oral magnesium citrate supplementation for several months and will be followed for clinical outcomes. This summary was prepared to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMagnesium Citrate 100 MG

initial intravenous treatment: Patients with magnesium levels 1-1.5 mg/dL will receive 2-4 grams of magnesium sulfate in the first 24 hours. Patients with magnesium levels 1.6-1.9 mg/dL will receive 1 gram of magnesium sulfate. participants with magnesium level ≥1 mg/dL, will be randomized, and oral magnesium therapy, Magnesium Citrate, ( or no treatment) will be started, and continued for at least three months. The experimental group will receive 400mg magnesium daily in two divided doses.


Locations(1)

Emek Medical Center

Afula, Israel

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NCT03088852


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