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RecruitingNot ApplicableNCT03100656

Study of Food Aversion in Patients With Anorexia Nervosa

Solving EPHX2 and Polyunsaturated Fatty Acid Interactions in Anorexia Nervosa

Sponsor

University of California, San Diego

Enrollment

300 participants

Start Date

Nov 10, 2016

Study Type

INTERVENTIONAL

Conditions

Anorexia Nervosa

Summary

This study uses a meal-challenge protocol to assess if patients with anorexia nervosa show a differential metabolism in response to food in comparison to healthy controls. This study determines how heritable and biochemical factors influence food metabolism in anorexia nervosa in order to develop more effective treatment strategies.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 55 Years

Inclusion Criteria3

  • Ill AN subjects will meet current Diagnostic and Statistical Manual of Mental Disorders (DSM V) diagnosis of AN, body mass index (BMI) between 11 kg/m² and 17.5 kg/m², or BMI \> 17.5 kg/m² with active eating disorder symptoms.
  • Recovered AN must meet the following criteria at time of study entry: 1) Current or past DSM V diagnosis of AN; 2) BMI between 18.5 kg/m2 and 30 kg/m2; 3) Having maintained a BMI of \>18.5 for at least one year.
  • Control must be healthy adolescent or woman negative on our screen for AN, other Axis I psychiatric illnesses, and having maintained a BMI of between 18.5-30 kg/m² since the age of 18.

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Interventions

OTHERA breakfast sandwich

A meat-based breakfast sandwich

Locations(2)

UC San Diego Altman Clinical and Translational Research Institute

La Jolla, California, United States

Program for Eating Disorders, Toronto General Hospital

Toronto, Ontario, Canada

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