RecruitingPhase 4NCT03102125

Allograft Dysfunction in Heart Transplant

Defining Mechanisms for Cardiac Allograft Dysfunction to Improve Allograft Longevity and Survival in Heart-Transplant Patients


Sponsor

Paul Kim

Enrollment

376 participants

Start Date

Oct 1, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at heart transplant recipients to better understand why some transplanted hearts stop working well over time — a condition called allograft dysfunction. Researchers are using a special type of MRI to assess the health of the transplanted heart. **You may be eligible if...** - You are 18 years or older - You received a heart transplant at least 3 months ago **You may NOT be eligible if...** - You had a confirmed episode of acute heart rejection in the past 3 months - You have had a recent heart attack or signs of heart blockage in the past 3 months - You have uncontrolled asthma or COPD (chronic lung disease) - You have a history of major seizures - You have certain types of heart rhythm problems (second or third degree heart block, sick sinus syndrome) - You have a pacemaker or other implanted electronic device that is not compatible with MRI - Your kidney function is significantly reduced (GFR below 30) - You have had a serious allergic reaction to MRI contrast dye or certain heart stress medications - Your blood pressure or heart rate is outside safe ranges - You have severe claustrophobia Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGRegadenoson

For use in stress myocardial perfusion imaging.


Locations(1)

UC San Diego

La Jolla, California, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT03102125


Related Trials