Biomechanical and Microstructural Properties of Ascending Aortic Aneurysms
BIOMECHANICAL AND MICROSTRUCTURAL PROPERTIES OF THE AORTIC WALL: A Pilot Study in Patients Undergoing Surgery for Ascending Aortic Aneurysms
Universitaire Ziekenhuizen KU Leuven
180 participants
Jan 1, 2017
OBSERVATIONAL
Conditions
Summary
An aortic aneurysm (thoracic or abdominal) is a permanent dilatation of the aorta caused by weakening in the arterial wall. The feared complication is aortic rupture or dissection, leading to potentially lethal aortic bleeding and associated with mortality rates up to 95%. The current diagnosis criteria do not suffice, therefore the goal of this study is the development of an improved biomechanics-based and microstructural-based diagnostic tool.
Eligibility
Inclusion Criteria3
- Patients suffering from thoracic aortic aneurysms (ATAA), asymptomatic or symptomatic.
- Patients with ruptured ATAA undergoing an emergency surgery.
- Signed informed consent.
Exclusion Criteria2
- Patients with ruptured ATAA due to trauma.
- The presence of any aneurysm feature that will prevent the collection of tissue samples suitable for the biomechanical and microstructural studies.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Tissue collection; microstructural testing of tissue; mechanical testing of tissue .
Image analysis of ECG-gated CT.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT03142074