RecruitingNCT03160274

Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions

Sponsor

The University of Texas Health Science Center at San Antonio

Enrollment

2,000 participants

Start Date

Oct 19, 2005

Study Type

OBSERVATIONAL

Conditions

Paraganglioma Pheochromocytoma Kidney Neoplasms Other Cancer Inherited Cancer Syndrome Associated Conditions Bone Cancer Thyroid Neoplasms

Summary

Pheochromocytomas and paragangliomas are neural crest-derived tumors of the nervous system that are often inherited and genetically heterogeneous. Genetic screening is recommended for patients and their relatives, and can guide clinical decisions. However, a mutation is not found in all cases. The aims of this proposal are to: 1) to map gene(s) involved in pheochromocytoma, and 2) identify genotype-phenotype correlations in patients with pheochromocytoma/paraganglioma of various genetic origins.

Eligibility

Plain Language Summary

Simplified for easier understanding

This study is examining the genetic causes of two rare adrenal gland tumors — pheochromocytoma and paraganglioma — to better understand why some people develop them and how genetics may play a role. **You may be eligible if...** - You have been diagnosed with a pheochromocytoma or paraganglioma (tumors of the adrenal glands or nearby nerve tissue) - You have a family member who has been diagnosed with these tumors - You have been diagnosed with a related condition associated with these tumors - You have a family member with a related condition **You may NOT be eligible if...** - Your diagnosis of pheochromocytoma, paraganglioma, or a related condition has not been confirmed by a doctor Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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