RecruitingPhase 1Phase 2NCT03185468

Intervention of Bladder Cancer by CAR-T

Intervention of Advanced or Metastatic Urothelial Bladder Cancer by 4SCAR-T Cell Therapies


Sponsor

Shenzhen Geno-Immune Medical Institute

Enrollment

20 participants

Start Date

Aug 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a Phase I/II and multicenter study designed to evaluate the efficacy and safety of 4SCAR-T cells in participants with locally advanced or metastatic urothelial bladder cancer (UBC) who have no further treatment available.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new immune cell therapy called CAR-T — where a patient's own immune cells are genetically engineered in a lab to find and destroy bladder cancer cells — for people with advanced or metastatic bladder cancer (including cancers of the urinary tract). **You may be eligible if...** - You have advanced or metastatic bladder or urinary tract cancer confirmed by tissue or lab test - Your cancer is measurable on imaging scans - You are in reasonably good health (able to carry out daily activities with minimal limitations) - Your blood counts and organ function are adequate - Your expected survival is at least 12 weeks **You may NOT be eligible if...** - You have received cancer treatment within the past 3 weeks - You are currently enrolled in another experimental treatment study - You are pregnant or breastfeeding - You have active autoimmune disease or serious infection Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

GENETIC4SCAR-PSMA

PSMA-specific 4th Generation CART

GENETIC4SCAR-FRa

FRa-specific 4th Generation CART


Locations(2)

Shenzhen Second People Hospital

Shenzhen, Gongdong, China

Shenzhen Geno-immune Medical Institute

Shenzhen, Guangdong, China

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NCT03185468


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