RecruitingNCT03209791
Ethanol Induces Skeletal Muscle Autophagy
Mechanisms of Skeletal Muscle Proteolysis With Ethanol Consumption: an Integrated Molecular Metabolic Approach
Sponsor
The Cleveland Clinic
Enrollment
40 participants
Start Date
May 18, 2015
Study Type
OBSERVATIONAL
Conditions
Summary
In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.
Eligibility
Min Age: 18 YearsMax Age: 65 Years
Inclusion Criteria7
- Alcoholic liver disease:
- clinical, biochemical, imaging criteria and liver biopsy where available
- Age 18 - 65 years old
- Controls:
- Serum liver transaminases (i.e. ALT and AST) 40 IU/L
- Normal liver ultrasound
- Age 18 - 65 years old
Exclusion Criteria10
- For both groups - alcoholic liver disease and controls:
- Poorly controlled diabetes mellitus (HbA1C>9.5 g/dl)
- Untreated Hyper- / hypo- thyroidism
- Patients on dialysis, renal disease with serum creatinine 1.5 mg/dL
- Active intravenous drug use
- History of bowel surgery or gastric bypass surgery
- Medications known to alter muscle protein metabolism (i.e. corticosteroids, tamoxifen, high-dose estrogen, testosterone or anabolic steroids)
- Metastatic disease, Advanced cardiac or pulmonary disease
- Pregnancy
- Coagulopathy- INR >1.4 and platelet count <80,000/ml.
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Interventions
OTHERBiopsies
Biopsy will be done on the Vastus Lateralis muscle in all groups
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03209791
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