RecruitingPhase 1NCT03240328

The Effect of Chimeric Antigen Receptor (CAR)-T Cell Therapy on the Reconstitution of HIV-specific Immune Function

The Effect of CAR-T Cell Therapy on the Reconstitution of HIV-specific Immune Function


Sponsor

Guangzhou 8th People's Hospital

Enrollment

40 participants

Start Date

Oct 4, 2017

Study Type

INTERVENTIONAL

Conditions

Summary

To study the safety and effectiveness of CAR-T Cell therapy on HIV patients whose plasma HIV has been successfully suppressed after cART, which is expected to enhance the res-constitution of HIV-specific immune function to assist the eradication of HIV reservoir.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a cutting-edge cell therapy (CAR-T cells) in people living with HIV to see if it can help restore the immune system's ability to fight the virus. **You may be eligible if...** - You have confirmed HIV infection - You have been on antiretroviral therapy (HIV medication) for more than 12 months - Your HIV viral load is undetectable (below 50 copies/ml) and your immune cell count (CD4) is above 350 - You have no serious liver, heart, or kidney disease **You may NOT be eligible if...** - You have an active Hepatitis B or Hepatitis C infection, or a serious opportunistic infection - You have a serious chronic illness like diabetes or mental illness - You have a history of pancreatitis from HIV medication - You are pregnant or breastfeeding - You have difficulty sticking to medical appointments or following a treatment plan Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALCAR-T cells

HIV-1 specific chimeric antigen receptor cells


Locations(1)

Guangzhou 8th People's Hospital

Guangzhou, Guangdong, China

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NCT03240328


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