RecruitingNot ApplicableNCT03246802

Partial Prostate Salvage High Dose Rate Brachytherapy

High Dose Rate Partial Prostate Brachytherapy as Salvage Treatment for Local Failures After Previous External Beam Radiotherapy

Sponsor

British Columbia Cancer Agency

Enrollment

30 participants

Start Date

Jan 1, 2018

Study Type

INTERVENTIONAL

Conditions

Recurrent Prostate Cancer

Summary

A dose-response relationship for radiation in the management of prostate cancer is well established. Local recurrence of prostate cancer after external beam radiotherapy occurs in at least 40% of patients treated because of inability to deliver sufficient dose through external beam techniques. These patients respond well to re-irradiation using brachytherapy with about 50% of selected patients remaining free of recurrence 5 years after salvage. Advanced imaging using multiparametric Magnetic Resonance Imaging (mpMRI) allows identification of the site of recurrence, permitting partial prostate salvage brachytherapy. There is extensive literature on Low Dose Rate salvage brachytherapy but less on High Dose Rate.

Eligibility

Sex: MALEMin Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a precise, targeted form of internal radiation (high dose rate brachytherapy) to treat prostate cancer that has come back in a specific area of the prostate after a patient previously received radiation therapy. **You may be eligible if...** - You are over 45 years old with a life expectancy of more than 10 years - Your prostate cancer came back after previous radiation therapy (external beam or seed implant), at least 3 years after your first treatment - Your PSA (a prostate cancer blood marker) is rising but still below 10, and it is doubling slowly (over 6 months) - Imaging shows the cancer has returned only in one spot in the prostate, with no spread - A biopsy has confirmed the cancer's return in that specific location - You have no history of inflammatory bowel disease or rectal surgery - You are in good physical condition and able to urinate reasonably well **You may NOT be eligible if...** - You do not meet the above criteria - You had a previous prostate surgery (TURP) - You are unable to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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