RecruitingNCT03255928

Dynamics of Platelet Activation in Patients With Ventricular Assist Device (VAD)

Analysis of the Platelet Activity State in Patients Implanted With Ventricular Assist Device (VAD)


Sponsor

Scientific Institute San Raffaele

Enrollment

60 participants

Start Date

Jun 29, 2017

Study Type

OBSERVATIONAL

Conditions

Summary

Consenting patients with end-stage heart failure that are implanted with/candidates for implant of a short-term/durable mechanical circulatory support device (e.g.: percutaneous microaxial pumps (Impella), extracorporeal membrane oxygenator (ECMO), Ventricular Assist Device (VAD) will be enrolled in the study. Aim of the study is to evaluate the patients' haemostatic and coagulation profile, how it interacts with the support device as well as the effect of antithrombotic drugs. From these data, it will be possible to derive the mechanisms triggering post-implant thromboembolic/hemorrhagic complications and to identify potential therapeutic targets.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study examines how platelets (tiny blood cells that help form clots) become activated in patients who receive mechanical heart assist devices — including short-term devices like Impella and ECMO, and long-term devices like left ventricular assist devices (LVADs). Understanding platelet activation can help reduce complications like stroke or device failure. You may be eligible if: - You are between 18 and 75 years old - You are a candidate for or have already received a short-term (Impella, ECMO) or long-term (LVAD) mechanical heart support device - You are willing to give informed consent You may NOT be eligible if: - You are under 18 years old Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTPAS assay, TGT

Evaluation of platelet function


Locations(1)

San Raffaele Scientifc Institute - Cardiothoracic Intensive Care Unit

Milan, MI, Italy

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NCT03255928


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