HIPEC in Ovarian Carcinoma Clinical Stage IIIC and IV During Interval Laparotomy

This study is testing whether adding a heated chemotherapy wash directly into the abdominal cavity (called HIPEC) during surgery improves survival for women with advanced ovarian cancer who have responded well to initial chemotherapy. **You may be eligible if...** - You are younger than 70 years old - You have been diagnosed with high-grade serous or low-grade endometrioid ovarian cancer at Stage IIIC or IVA (with fluid around the lungs only) - You have received 3–4 cycles of carboplatin and paclitaxel chemotherapy and shown at least a 50% response - During surgery, your surgeon is able to remove almost all visible tumor (less than 2.5 mm remaining) - Your heart, liver, kidneys, lungs, and blood counts are in adequate condition **You may NOT be eligible if...** - You have heart failure or coronary artery disease - You have previously received chemotherapy for another cancer - You have a history of neuropsychiatric disease - Severe bleeding occurs during surgery - You need more than 2 bowel reconnections during surgery Talk to your doctor to see if this trial is right for you.