Liquid Biopsy in Mature B-cell Tumors
Prospective, Observational, Multi-centred, Non-interventional Research Project on Plasma Cell Free DNA Genotyping as a Tool to Inform Mature B-cell Tumor Management
Oncology Institute of Southern Switzerland
444 participants
Sep 1, 2017
OBSERVATIONAL
Conditions
Summary
The study aims at assessing whether cell free DNA genotyping can improve the accuracy of early prediction of cure in mature B-cell tumor patients and whether it represents an accessible source of tumor DNA for the sensitive identification of genetic biomarkers that refine the diagnostic workup, stratify prognosis and identify the emergence of drug-resistance mutations during treatment.
Eligibility
Inclusion Criteria4
- Male or female adults 18 years or older
- Documented diagnosis of mature B-cell tumor according to WHO 2008 criteria
- Willing and able to comply with scheduled study procedures
- Evidence of a signed informed consent
Interventions
Assessing whether plasma cell free DNA improves the accuracy of early prediction of cure in mature B-cell tumor patients and whether it represents an accessible source of tumor DNA for the sensitive identification of genetic biomarkers that, at disease presentation, refine the diagnostic workup in mature B-cell tumor patients and, upon treatment, early identify the emergence of resistance mutations.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03280394