The Neurobiological Effect of 5-HT2AR Modulation

Exclusion Criteria32

• Presence of or previous primary psychiatric disease (DSM axis 1 or WHO ICD-10 diagnostic classifications) or in first-degree relatives.
• Previous or present neurological condition/disease, significant somatic condition/disease or intake of drugs suspected to influence test results.
• Non-fluent Danish language skills.
• Vision or hearing impairment.
• Previous or present learning disability.
• Pregnancy.
• Breastfeeding.
• Contraindications in regard to MRI scanning.
• Alcohol or drug abuse.
• Allergy to test drugs.
• Participation in studies in which participant has received more than 10 mSv of radiation or other significant exposure to radiation.
• Abnormal ECG or intake of QT prolonging medication.
• Previous significant side-effects in regard to hallucinogenic drugs.
• Use of hallucinogenic drugs 6 months previous to inclusion.
• Blood donation 3 months before and after project participation
• Body weight under 50 kg.
• Plasma ferritin levels outside normal range
• Presence of or previous primary psychiatric disease (DSM IV axis 1 or WHO ICD-10 diagnostic classifications).
• Presence of or previous primary psychiatric disease with psychosis symptoms or hypomania (DSM IV axis 1 \[drug/alcohol abuse/dependence, schizophrenia and other psychoses\] or WHO ICD-10 diagnostic classifications \[F10-29, as well as F30-39 with psychotic symptoms, F60\]) in first-degree relatives (parents or siblings).
• Previous or present neurological condition/disease, significant somatic condition/disease or intake of drugs suspected to influence test results.
• Non-fluent Danish language skills or pronounced vision or hearing impairment.
• Previous or present learning disability.
• Pregnancy.
• Breastfeeding.
• Contraindications in regard to MRI scanning.
• Alcohol or drug abuse.
• Allergy to test drugs.
• Abnormal ECG or intake of QT prolonging medication.
• Previous significant side-effects in regard to hallucinogenic drugs.
• Previous use of hallucinogenic drugs.
• Body weight under 45 kg.
• Ethical concerns regarding the administration of a psychedelic drug.