The Effects of the Female Hormones on Cerebral Perfusion
The Effects of the Female Sex Hormones and Hormonal Contraception on Cerebral Perfusion
University Ghent
62 participants
Oct 3, 2016
OBSERVATIONAL
Conditions
Summary
Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the variations in cerebral perfusion and other brain parameters (grey matter, resting-state brain activity, brain connectivity and white matter diffusion) caused by the female sex hormones and hormonal contraception.
Eligibility
Inclusion Criteria2
- Bachelor or Master student
- Minimum of 3 months not using contraception of using Deso20
Exclusion Criteria8
- No informed consent
- MRI-contraindications
- Claustrophobia
- Pregnancy or breastfeeding
- Chronic diseases and chronic medication use
- Smoker
- Drug use
- Abuse of alcohol and caffeine
Interventions
Several MRI scan modalities: MPRAGE (structural scan), arterial spin labeling (cerebral perfusion), resting state functional-MRI (fMRI, cerebral activity) and diffusion MRI (white matter diffusion and white matter tracts).
During MRI: heart rate, end-tidal carbon dioxide (CO2), respiratory rate and skin conductance
Blood sample after MRI-session: measurement of hematocrit, hemoglobin, estradiol, progesterone, follicle stimulation hormone and luteinizing hormone.
Measuring blood pressure before and after MRI-scan
Measuring body temperature before and after MRI-scan
Questionnaires at the start of the study on lifestyle. Additionally, a questionnaire before each scan session on the actual state of the volunteer (e.g. mood, caffeine consumption, alcohol, medication, etc.)
Test for pregnancy using a pregnancy dipstick test
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03299179