Pancreatic Cancer Adaptive Neoadjuvant Chemotherapy Trial

This study is testing an adaptive chemotherapy approach for pancreatic cancer patients — adjusting or changing treatment regimens based on how well the tumour is responding before surgery, with the goal of shrinking the tumour enough to remove it completely. **You may be eligible if...** - You are 18 or older - You have been diagnosed with pancreatic cancer confirmed by a tissue sample - Your cancer is potentially removable by surgery - You are well enough to receive chemotherapy (ECOG performance status less than 2) - You are willing and able to give written consent **You may NOT be eligible if...** - Your cancer has spread widely and cannot be removed by surgery - You are not well enough for chemotherapy - You have already received treatment for this pancreatic cancer - You have serious organ problems that would prevent treatment Talk to your doctor to see if this trial is right for you.