Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation
Central Hospital, Nancy, France
700 participants
Oct 1, 2019
INTERVENTIONAL
Conditions
Summary
The study concerns donors and patients receiving allogeneic stem cell haematopoietic transplantation. The aim of the study is to analyse HSC graft content in immune effector T (naive, memory, activated, exhausted) and immunoregulatory cell subtypes (Tregs, iNKT, MDSC) and correlate the results with post-transplant immune reconstitution of those different cell subtypes and clinical events (graft-versus-host-disease, relapse, infections). An ancillary study will focus on the impact of microbiota dysbiosis on post-transplant immune response and regulatory cell subsets.
Eligibility
Inclusion Criteria2
- patient of the Nancy CHRU, for whom a CSH allograft is planned. or
- hematopoietic stem cell donors received at Nancy's CHRU for the duration of the research
Exclusion Criteria2
- Positive HIV
- active hepatitis B or C infection
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Interventions
Additional blood sample before graft, D0, D7, D15, D21, D30, D60, D90, D180, Y1, Y2
Additional bone marrow aspiration before graft, D30, D90, Y1
Before donation
Allogeneic hematopoietic stem cell sample
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT03357172