RecruitingNCT03358979
Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)
Sponsor
Fondation Ophtalmologique Adolphe de Rothschild
Enrollment
100 participants
Start Date
Dec 14, 2017
Study Type
OBSERVATIONAL
Conditions
Summary
Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers before and after initiation of a treatment.
Eligibility
Min Age: 18 Years
Inclusion Criteria5
- Patients:
- years and over
- Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes
- Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced
- \- 18 years and over
Exclusion Criteria4
- Control subjects:
- Wearer of contact lenses
- Topical ocular treatment
- Known pregnancy or breastfeeding
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03358979
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