Biological Dating of Cerebral Ischemia With GST-π/PRDX1 to Detect Patients With Stroke of Unknown Onset Within the Therapeutic Window of Thrombolysis
Biological Dating of Cerebral Ischemia With Glutathion S-Transferase-π (GST-π) and Peroxyredoxin 1 (PRDX1) to Detect Patients With Stroke of Unknown Onset Within the Therapeutic Window of Thrombolysis
Central Hospital, Nancy, France
930 participants
Oct 15, 2018
INTERVENTIONAL
Conditions
Summary
The FLAG1 study will assess the diagnostic performance of biomarkers Glutathion S-Transferase-π (GST-π) and Peroxyredoxin 1 (PRDX1) to identify cerebral infarction of less than 4,5 hours in a population of patients with neurological deficiency of less than 12 hours.
Eligibility
Inclusion Criteria7
- Patients over 18 years old
- Patients with symptoms consistent with stroke and a National Institute of Health Stroke Score ≥3 at the inclusion time
- For patients with time of symptom onset is <4.5h at inclusion, the time of symptom onset has to be precisely known, with a margin of error not exceeding 30 minutes (through patient or witness interview)
- last time patient presented no deficit must be less than 24 hours,
- symptoms must have been first recognized more than 4.5 hours before blood draw.
- Possibility to perform MRI within the 30 minutes following blood collection
- Person affiliated to or beneficiary of a social security plan
Exclusion Criteria6
- Persons referred in articles L.1121-5, L.1121-7, L.1121-8 and L.1122-2 of the French Public Health Code: Pregnant, parturient or breastfeeding woman ; Minor person (non-emancipated) ; Adult person under legal protection (any form of public guardianship) ; Adult person incapable of giving consent and not under legal protection.
- Persons deprived of liberty for judicial or administrative decision.
- Persons subject to psychiatric care under articles L.3212-1 and L.3213-1 of the French Public Health Code.
- Known cancer in progression.
- Known cirrhosis.
- Myocardial Infarctions, stroke, Subarachnoid hemorrhage or intracranial injury within 3 months prior to enrolment.
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Interventions
Blood sample retrieved for biological assessment and biobanking
Locations(5)
View Full Details on ClinicalTrials.gov
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NCT03364296