Sentinel Node Mapping in High Risk Endometrial Cancer

This trial is evaluating a technique called sentinel node mapping — a method to identify the specific lymph nodes most likely to contain cancer cells — in women with high-risk uterine cancer (endometrial cancer), to see if it can accurately replace the more extensive removal of large numbers of lymph nodes. **You may be eligible if...** - You have been diagnosed with a high-grade type of uterine cancer (including grade 3 endometrioid, serous, clear cell, or carcinosarcoma) - You have lower-grade endometrial cancer but with deep invasion into the uterine wall (50% or more) or cancer involving the cervix - You are medically suitable for a full lymph node removal procedure - You have signed informed consent **You may NOT be eligible if...** - You previously had a hysterectomy at a different institution - The cancer has spread outside the uterus (to the abdomen, organs, or lymph nodes) - You previously had pelvic lymph node removal surgery Talk to your doctor to see if this trial is right for you.