Intralesional 5-Fluorouracil (5FU), Topical Calcipotriene Treatment for SCC

This trial is testing a combination treatment — injections of a chemotherapy drug (5-fluorouracil, or 5-FU) directly into the tumor alongside a topical vitamin D cream (calcipotriene) applied to the skin — for treating squamous cell carcinoma (a common type of skin cancer) on the lower legs. **You may be eligible if...** - You are 18 years or older - You have been diagnosed by biopsy with squamous cell skin cancer on your knee or below, measuring between 1.0 cm and 2.0 cm in diameter - Your expected survival is at least 12 months - You are not currently on any other experimental treatment - You are willing to follow the study instructions and sign an informed consent form - Your overall health is good (performance status 0 or 1) **You may NOT be eligible if...** - Your skin cancer is smaller than 1 cm or larger than 2 cm - The cancer is located above the knee - You are currently participating in another clinical trial - Your health is too poor to participate Talk to your doctor to see if this trial is right for you.