RecruitingNot ApplicableNCT03384108
In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells
In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells in Healthy Subjects Using Stable Isotope Resolved Metabolomics: A Pilot Study
Sponsor
Mayo Clinic
Enrollment
20 participants
Start Date
Sep 1, 2017
Study Type
INTERVENTIONAL
Conditions
Summary
This pilot study will first establish the feasibility of an in vivo methodology of assessing the utilization of glutamine into the TCA cycle of normal bone marrow plasma cells from healthy subjects while comparing it to an ex vivo approach
Eligibility
Min Age: 18 YearsMax Age: 60 Years
Inclusion Criteria2
- Ages 18-60
- Able to provide written consent
Exclusion Criteria7
- Renal Failure
- Pregnancy
- Active steroid use
- Active liver Disease
- Anemia (Hemoglobin < 12.5 g/dL in men and < 11.5 g/dL in women)
- H/O alcohol use (average > 2 drinks per day)
- BMI > 30
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Interventions
OTHER5-13C-Glutamine
Intravenous infusion of 5-13C-Glutamine
OTHERBone marrow aspiration
Bone marrow aspiration of bone marrow aspirate
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03384108
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