RecruitingPhase 1Phase 2NCT03384238

Panitumumab-IRDye800 in Patients With Pancreatic Cancer Undergoing Surgery

A Phase I/II Study Evaluating the Safety and Pharmacokinetics of Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Pancreas Cancer During Surgical Procedures


Sponsor

George Poultsides

Enrollment

27 participants

Start Date

Feb 7, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

This phase I/II trial studies the side effects and best dose of panitumumab-IRDye800 and to see how well it works in finding cancer in patients with pancreatic cancer who are undergoing surgery. Panitumumab-IRDye800 is a combination of the antibody drug panitumumab and IRDye800CW, an investigational dye that can be seen using a special camera. Panitumumab-IRDye800 may attach to tumor cells and make them more visible during surgery in patients with pancreatic cancer.


Eligibility

Min Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing whether a special imaging dye (called panitumumab-IRDye800) injected before surgery can illuminate pancreatic cancer tumors during the operation, helping surgeons see the edges of the tumor more clearly and potentially improve the chances of removing all of the cancer. **You may be eligible if...** - You have been diagnosed with pancreatic cancer (adenocarcinoma), either suspected or confirmed by biopsy - You are scheduled for standard surgery with the intent to remove the cancer - Your life expectancy is more than 12 weeks - Your overall health is good (Karnofsky score of at least 70%, or ECOG score 0 to 1) - Your blood counts and key minerals (hemoglobin, platelets, magnesium, potassium, calcium) meet the required levels **You may NOT be eligible if...** - Your surgery is not planned with curative intent - Your blood counts or organ function do not meet the required levels - Your overall health is too poor for surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREFluorescence Imaging

Undergo fluorescence imaging

BIOLOGICALPanitumumab

Given IV

DRUGPanitumumab-IRDye800

Given IV


Locations(1)

Stanford University, School of Medicine

Palo Alto, California, United States

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NCT03384238


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