RecruitingNot ApplicableNCT03419689

Study Looking at Biomarkers in Ovarian Cancer

Biomarker Discovery Project in High Grade Serous Ovarian Cancer


Sponsor

University Health Network, Toronto

Enrollment

510 participants

Start Date

Jan 8, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

This is a sample study that will collect biological samples (blood, tumor tissue, ascites, and/or other fluids) from gynecological cancer patients for biomarker research. In addition, the results of the testing done on the samples will be given to the participant's treating physician who may use the information to guide treatment decisions.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting blood, fluid, and tumor tissue samples from patients with advanced ovarian cancer to look for biological markers (biomarkers) that can help predict how the cancer will respond to treatment. **You may be eligible if...** - You have been diagnosed with stage III or IV high-grade serous ovarian, fallopian tube, or primary peritoneal cancer - You are 18 years or older - You are in generally good health (ECOG performance status 0–1) - Your life expectancy is 6 months or more - You are willing to provide blood, fluid, or tissue samples - Archived tumor tissue is available (if enrolling after surgery) **You may NOT be eligible if...** - You have a different type of ovarian cancer (not high-grade serous) - You are not in suitable health to participate - You are unwilling to provide samples Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURETumour tissue collection

Tumour tissue will be taken from samples already removed from surgery or biopsy or by new tumour biopsies: * At the time of diagnosis or progression * Any surgical procedures for management of tumour related medical conditions * At each subsequent relapse or disease progression

PROCEDUREBlood sample collection

Blood samples will be taken: * At the time of first diagnosis * About 1 week after starting any treatment * At each radiological response assessment * At each subsequent relapse or disease progression

PROCEDUREAscites Collection

Ascites will be collected if paracentesis is required during any of the following time points: * At the time of diagnosis or progression * Any surgical procedures for management of tumour related medical conditions * At each subsequent relapse or disease progression

PROCEDUREFluid Collection

Additional fluid will be collected at any time a procedure for clinical management that involves the drainage of fluid (i.e. thoracentesis, or drainage of cystic lesion) is required.


Locations(7)

Royal Victoria Regional Health Centre

Barrie, Ontario, Canada

Juravinski Cancer Centre

Hamilton, Ontario, Canada

Kingston Health Sciences Centre

Kingston, Ontario, Canada

London Health Sciences Centre

London, Ontario, Canada

The Ottawa Hospital Cancer Centre

Ottawa, Ontario, Canada

Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

Princess Margaret Cancer Centre

Toronto, Ontario, Canada

View Full Details on ClinicalTrials.gov

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NCT03419689


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