RecruitingNot ApplicableNCT03422302

Continuous Positive Airway Pressure Device or Deep Inspiration Breath Hold in Reducing Tumor Motion in Patients Undergoing Stereotactic Body Radiation Therapy for Lung Cancer

Measuring the Effectiveness of a Continuous Positive Airway Pressure (CPAP) Device to Reduce Tumor Motion and Increase Lung Volume Expansion in Patients Undergoing Stereotactic Body Radiotherapy (SBRT) for Tumors That Move With Respiration


Sponsor

M.D. Anderson Cancer Center

Enrollment

30 participants

Start Date

Mar 16, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

This pilot phase I/II trial studies how well a continuous positive airway pressure device or deep inspiration breath hold works in reducing tumor movement in patients undergoing stereotactic body radiation therapy (SBRT) for lung cancer. The continuous positive airway pressure device works by blowing air into the lungs while patients wear a face mask or nozzle to help expand their airways and lungs. Deep inspiration breath hold is a standard technique that uses active breath-holding to restrict movement of the body. Using a continuous positive airway pressure device may work better than deep inspiration breath hold in lowering the amount of tumor movement during stereotactic radiation body therapy.


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • The patient will receive stereotactic body radiotherapy in the Thoracic Radiation Oncolcogy Service at MD Anderson.

Exclusion Criteria8

  • The patient has a contra-indication for using a CPAP device.
  • The patient has not signed a study-specific informed consent for this study.
  • The patient is uncooperative.
  • The patient has reduced consciousness.
  • The patient has sustained trauma or burns to the face.
  • The patient has undergone any facial, esophageal, gastric or sinus surgery within the last 3 months.
  • The patient has idiopathic pulmonary fibrosis (IPF) as documented in their medical history.
  • Adults who are unable to consent, individuals who are not yet adults, pregnant women and prisoners will be excluded from this study.

Interventions

DEVICEBiphasic Positive Airway Pressure

Receive BiPAP

PROCEDUREComputed Tomography

Undergo CT simulation scans

PROCEDUREContinuous Positive Airway Pressure

Receive CPAP

PROCEDUREDeep Inspiration Breath Hold

Complete DIBH

RADIATIONRadiation Therapy Treatment Planning and Simulation

Undergo CT simulation scans

RADIATIONStereotactic Body Radiation Therapy

Undergo SBRT


Locations(1)

M D Anderson Cancer Center

Houston, Texas, United States

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NCT03422302


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