Alternation in the Human Microbiome With Commonly Used Topical Medications
Alterations in the Human Microbiome With Commonly Used Topical Medications
University of California, Davis
24 participants
Jan 28, 2013
INTERVENTIONAL
Conditions
Summary
The global aim of this study is to investigate how the human microbiome changes from baseline with commonly used topical medications such as topical antifungals, low to mid potency topical steroids and emollients. The specific aims are as follows: 1. Investigate whether ketoconazole cream, a commonly used topical antifungal, causes alterations in the human skin microbiome with short-term use. 2. Investigate whether desonide 0.05 % ointment, a commonly used low potency topical steroid, alters the human microbiome with short-term use.
Eligibility
Inclusion Criteria1
- Adults at least 18 years of age.
Exclusion Criteria8
- Individuals with known chronically active skin diseases, including atopic dermatitis, psoriasis, seborrheic dermatitis, other autoimmune and inflammatory skin conditions.
- Patients with a history of skin cancer, multiple nevi, or other isolated lesions will not be excluded.
- Individuals who have used topical, intravenous, intramuscular, or oral antibiotics within the last 6 months
- Individuals with known allergies to any of the study medications.
- Individuals younger than 18 years of age.
- Adults unable to consent
- Non-English speaking individuals. Given the complexity in the instructions that subjects will need to follow for proper sample collection, we will not seek to recruit non-English speaking individuals for this pilot study.
- Prisoners
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Interventions
Desonide 0.05% ointment topically twice daily for two weeks
Ketoconazole 2% cream topically twice daily for two weeks
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03437005