RecruitingNot ApplicableNCT03446326

Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates

Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates and Body Position - a Pacemaker Based Study

Sponsor

University of Calgary

Enrollment

25 participants

Start Date

Jan 1, 2018

Study Type

INTERVENTIONAL

Conditions

Vasovagal Syncope

Summary

The investigators will seek to determine the effects of different heart rates on both stroke volume and cardiac output using non-invasive hemodynamic assessments. In order to safely manipulate the HR, the investigators will study patients with permanent pacemakers in whom heart rate manipulation can be done in a safe and non-invasive manner.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria3

Age 18-70 years (inclusive)
Implanted permanent pacemaker or implanted defibrillator capable of atrial and ventricular pacing
LV ejection fraction \>50%

Exclusion Criteria2

Unable or unwilling to provide informed consent
Clinical need for a cardiac resynchronization device

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Interventions

DEVICEPacing

Assess the non-invasively determined stroke volume and cardiac output response at different paced heart rates in patients with a cardiac pacemaker or implanted defibrillator with preserved ejection fractions (LVEF≥50%)