RecruitingNCT03466944

PUMA (Paediatric Osseous Marrow Assessment)

Quantitative Magnetic Resonance Imaging of Bone Marrow in a Paediatric Population With Leukaemia (PUMA)

Sponsor

Institute of Cancer Research, United Kingdom

Enrollment

12 participants

Start Date

Mar 5, 2018

Study Type

OBSERVATIONAL

Conditions

Leukaemia

Summary

This is a pilot cancer imaging study investigating change in the apparent diffusion coefficient (ADC) at a single time point post-transplantation in patients. The treatment is bone marrow transplant as per standard patient care, without change for trial purposes. Its main aim is to evaluate the engraftment of bone marrow after transplantation performing functional Magnetic Resonance Imaging (MRI) of the lumbar spine and pelvis at baseline and after 2-3 weeks after the transplantation (according to the appearances of raised white blood cells).This will enhance the understanding of bone marrow features on imaging at engraftment and improve the management of children/young adults who suffer acute leukaemia. Following allogenic haemopoietic stem cell transplantation, changes in bone marrow apparent diffusion coefficient (ADC) are measurable at the point of engraftment and in conjunction with peripheral blood counts may provide a future biomarker of successful clinical outcome.

Eligibility

Min Age: 5 YearsMax Age: 24 Years

Plain Language Summary

Simplified for easier understanding

This study (called PUMA) is testing whether a special MRI scan can replace bone marrow biopsies (painful needle procedures) in children and young adults with leukemia who are being prepared for a stem cell transplant, by checking the bone marrow non-invasively through imaging. **You may be eligible if...** - You are between 5 and 24 years old - You have relapsed or high-risk acute leukemia (either lymphoblastic or myeloblastic) and are scheduled for a stem cell (bone marrow) transplant - You can cooperate during an MRI scan without needing sedation or general anesthesia - You are able to lie still and flat throughout the scan **You may NOT be eligible if...** - You cannot cooperate with the scan - You have metal implants (like braces or surgical hardware) that are not compatible with MRI - You have claustrophobia - You cannot lie flat during the scan - Your diagnosis has not been confirmed - You have bone or metabolic conditions that would affect the results - Parental consent and your own verbal agreement have not been obtained Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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