Plasmodium Immunotherapy for Breast and Liver Cancers

This trial is testing an unconventional cancer treatment called Plasmodium immunotherapy — where patients are deliberately infected with a specially controlled, weakened form of malaria parasite — to see if the resulting immune response can be directed to fight advanced breast cancer or liver cancer. **You may be eligible if...** - You are between 18 and 70 years old - You have advanced breast cancer or advanced liver cancer confirmed by biopsy and imaging, with measurable tumors - You have already received at least one standard treatment for your cancer - Your last chemotherapy or radiation was at least 1 month ago; last targeted therapy was at least 5 half-lives ago - Your general health and organ function are acceptable (blood counts near normal, liver and kidney function near normal, ECOG 0–1) - Your expected survival is at least 6 months **You may NOT be eligible if...** - You have a serious hemoglobin disorder (like sickle cell disease or thalassemia) or severe G6PD deficiency - Your spleen has been removed or is greatly enlarged - You have drug or alcohol dependence - You have uncontrolled serious illness (severe infection, uncontrolled blood pressure, heart failure, liver/kidney failure) - You are receiving other anti-cancer treatments simultaneously - You are pregnant, breastfeeding, or have a positive pregnancy test Talk to your doctor to see if this trial is right for you.