RecruitingNot ApplicableNCT03475173

New Non-invasive Modalities for Assessing Retinal Structure and Function

New Non-invasive Modalities for Assessing Retinal Structure and Function:Preliminary Investigation

Sponsor

Randy Kardon

Enrollment

500 participants

Start Date

May 6, 2019

Study Type

INTERVENTIONAL

Conditions

Hemianopia Leber Hereditary Optic Neuropathy Ischemic Optic Neuropathy Branch Retinal Artery Occlusion Acute Zonal Occult Outer Retinopathy

Summary

This study investigates a new technology to assess the structure and function inside the eye. Retinal imaging of subjects with inner and outer retinal defects to detect areas of abnormal structure and function compared to other visual function tests.

Eligibility

Min Age: 18 YearsMax Age: 99 Years

Inclusion Criteria4

Controls:
Normal eye exam in last 2 years
Defined structural defect to include those with Ischemic optic neuropathy, branch retinal artery occlusion (BRAO), hemianopia or visual field defect that respects the vertical meridian, inherited mitochondrial optic neuropathies such as Leber's and Dominant Optic Neuropathy, other retinopathies or optic neuropathies.
AZOOR (acute zonal occult outer retinopathy) or other focal or diffuse outer photoreceptor loss of function

Exclusion Criteria6

Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Any abnormalities of the retina or optic nerve that could affect metabolism of the retina outside of normal.
Subjects with Inner Retina Defect:
Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.
Subjects with Outer Retinal Defect:
Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.
The 450 total is to allow for exclusion of some subjects or in the event that the enrolled subject blinks too much or cannot fixate on a visual target adequately to maintain the same eye position during the short imaging interval. We hope to have a total of 450 (50 controls and 400 patients)

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Interventions

DEVICELSFG-NAVI

laser-speckle blood flow of ocular arteries and veins

Locations(1)

University of Iowa Department of Ophthalmology

Iowa City, Iowa, United States

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NCT03475173

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