Manual Versus Targer-controll Infusion in Reduction of Awareness and Dreaming
Reduction of Awareness and Dreaming During Neurosurgical Procedures Using Target- Controlled Infusion, Comparison With Manual Total Intravenous Anesthesia TIVA.
University Hospital Hradec Kralove
80 participants
Mar 16, 2018
INTERVENTIONAL
Conditions
Summary
This study compares manual total intravenous anesthesia (TIVA) and target-controll infusion (TCI) in reduction of awareness and dreaming, and the haemodynamical stability during operation. Half of patients will be anesthetized using manual TIVA and other half using TCI.
Eligibility
Inclusion Criteria4
- Glasgow Coma scale 15
- ASA Physical Status Classification System I - III
- planed surgery for brain tumor to 5 hours
- postoperative awakening
Exclusion Criteria6
- NYHA III, IV
- abuse of stimulating drugs, grass, alcohol dependence
- BMI over 40 in females and over 35 in men
- propofol alergie
- awake operations
- postoperative arteficial ventilation
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Interventions
Induction and anesthesia will be done by using Gepth model for sufentanil and Schnider effect model for propofol. Anesthetics will be aplicated using infusion pump Agilia (Fresenius Kabi). Another titration will be according to target value of entropy between 40 and 60 and surgical pleth index below 35.
Induction of anesthesia will be done by titrating of propofol to the dose of 1.2 mg/kg and sufentanil 5-10 ug according to body weight, maintaining of anesthesia using continuous infusion of propofol 5 mg/ kg/hour and sufentanil 35 ug/hour to reach the target value of entropy between 40 and 60 and surgical pleth index below 35.
Locations(1)
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NCT03476213