RecruitingNot ApplicableNCT03481868
EPIgenetics and in Vivo Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors
Collection of Biological Resources During Medical Care of Patients With Chronic Myeloid Leukemia (CML) in Chronic Phase for an Epigenetic Study of Leukemic Stem Cells
Sponsor
University Hospital, Clermont-Ferrand
Enrollment
160 participants
Start Date
Feb 1, 2018
Study Type
INTERVENTIONAL
Conditions
Summary
Primary objective : To identify epigenetic dysregulations of in vivo TKI-resisting CML cells Hypothesis : An epigenetic dysregulation is involved in the in vivo survival of a CML cell subclone despite the use of TKIs
Eligibility
Min Age: 18 Years
Inclusion Criteria7
- Patient newly diagnosed for Chronic Myeloid Leukemia in chronic phase
- Patient older than 18 years old
- Patient who received no treatment for CML at the time of sampling on D0
- Intention of prescription with first-line treatment with TKI only
- Choice of first-line CML treatment by TKI only
- Patient having signed an informed consent
- Patient with a social security system
Exclusion Criteria3
- Contra-indication to the use of TKI
- Probability of poor compliance during treatment
- Patients already treated for CML
Interventions
BIOLOGICALCollection of blood and bone marrow
Collection of blood and bone marrow in order to identify epigenetic abnormalities and their consequences in surviving CML cells after 3 months of TKI treatment
Locations(16)
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NCT03481868
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