Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma

This trial is testing a combination of chemotherapy followed by a procedure called irreversible electroporation (IRE, also known as NanoKnife) — which uses electrical pulses to destroy cancer cells without heat — in patients with Stage III pancreatic cancer that has not yet spread to distant organs. **You may be eligible if...** - You are 18 or older - You have been diagnosed with Stage III pancreatic cancer (locally advanced, meaning it has grown into nearby blood vessels but has not spread to other organs) - Your tumor is measurable on imaging - Your kidney function is adequate - You have recovered well from any prior surgery **You may NOT be eligible if...** - You are currently enrolled in another cancer treatment clinical trial - You are pregnant or breastfeeding - You have a cardiac pacemaker or implantable cardioverter-defibrillator (ICD) that cannot be turned off during the IRE procedure - You have non-removable metal implants within 1 cm of the tumor - You had a heart attack within the past 3 months Talk to your doctor to see if this trial is right for you.