RecruitingPhase 4NCT03490929

CEUS for Blunt Abdominal Trauma in Children

Contrast Enhanced Ultrasonography for Blunt Abdominal Trauma Imaging in Children


Sponsor

Children's Hospital of Philadelphia

Enrollment

146 participants

Start Date

Jun 1, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

Children with blunt abdominal trauma often get a CT as the first line imaging to evaluate for intra-abdominal organ injury. CT scans have some downsides with regard to radiation exposure, costs, and need for transport. Contrast enhanced ultrasonography has recently shown some promise as a way to detect intra-abdominal organ injury and may be able to replace the need for conventional CT scanning, without the need for ionizing radiation and the ability to be performed at the bedside.


Eligibility

Min Age: 0 YearsMax Age: 17 Years

Inclusion Criteria3

  • Hemodynamically stable (defined as not needing massive transfusion protocol and not undergoing an emergent surgical procedure within the next hour)
  • History of or suspicion for blunt abdominal trauma
  • Abdominal CT ordered or obtained

Exclusion Criteria3

  • History of allergic reaction to Lumason, sulfur hexaflouride, sulfur hexafluoride lipid microsphere components, or other ingredients in Lumason (polyethylene glycol, distearoylphosphatidylcholine (DSPC), dipalmitoylphosphatidylglycerol sodium (DPPG-Na), palmitic acid)
  • Co-existing penetrating abdominal trauma
  • Known congenital or acquired heart disease

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Interventions

DRUGSulfur Hexafluoride Lipid Type A Microspheres 25 MG Intravenous Powder for Suspension [LUMASON]

injection of Lumason (ultrasound contrast agent)

DEVICEcontrast-enhanced ultrasound

ultrasound of the abdomen after injection of ultrasound contrast agent (Lumason)


Locations(2)

Mayo Clinic

Rochester, Minnesota, United States

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

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NCT03490929