RecruitingNCT03491605

Surveillance and Tracking the Outcomes of Chronic Latent EBV Infection

Study to Surveil and Track the Outcomes of Chronic Latent EBV Infection Based on Healthy Volunteers Undergoing Routine Inspection

Sponsor

Huazhong University of Science and Technology

Enrollment

10,000 participants

Start Date

Jul 1, 2019

Study Type

OBSERVATIONAL

Conditions

EBV Infection

Summary

Immunocompetent subjects with high load of Epstein-Barr virus DNA (EBV-DNA) in peripheral blood will be enrolled and prospectively followed up to track the natural histories of the chronic high load of EBV virus. The primary goal of this study is to explore the association of peripheral high load of EBV with the hematological malignancies, and second goal is to investigate the genetic mechanisms of immune escape and tumorigenesis of chronic EBV infection.

Eligibility

Inclusion Criteria2

immunocompetent subjects who was found to have high EBV-DNA load （\>1×103 copies/ml）in peripheral blood during the physical examination
Willing to be followed up by telephone or face-to-face interview

Exclusion Criteria7

Subjects with defined immunodeficiency
Subjects who have taken or are going to take immunosuppressive drugs.
Subjects Diagnosed a validated hematopathy
Subjects diagnosis as precancerous lesion or malignant tumor and the life expectancy is less than 1 year.
psychological illness which does not allow subjects to understand the study and participate following his own free will
Pregnant woman
no written informed consent

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