Testing the Combination of Two Approved Chemotherapy Drugs and Radiation Prior to Surgery in Localized Pancreatic Cancer

This trial is testing whether combining two chemotherapy drugs (gemcitabine and nab-paclitaxel) with radiation therapy before surgery gives better results than current standard pre-surgery treatment in patients with localized, potentially removable pancreatic cancer. **You may be eligible if...** - You have been diagnosed with adenocarcinoma (the most common type) of the pancreas, confirmed by tissue or cell sampling - Your cancer is localized and potentially removable by surgery - You are 18 or older - You are in good overall health (ECOG 0 or 1 — able to perform normal activities) - You have not received any previous treatment for pancreatic cancer - Your blood counts, liver, and kidney function meet minimum requirements - You do not have an active serious infection **You may NOT be eligible if...** - Your cancer has spread to other organs (metastatic) or is considered borderline resectable (too close to major blood vessels) - You have had another cancer within the past 5 years (minor exceptions apply) - You have an active uncontrolled infection - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.