Autologous Ovarian Tissue Transplantation
University of Pittsburgh
5 participants
Mar 1, 2021
INTERVENTIONAL
Conditions
Summary
Chemotherapy and radiation for cancer and other conditions can cause infertility. Several centers around the world are cryopreserving ovarian tissue from these patients though an experimental protocol, including the Fertility Preservation Program in Pittsburgh (protocol PRO08050491). The objective of this study is to study the efficacy and safety of autologous tissue transplantation in patients diagnosed with primary ovarian insufficiency after chemotherapy and/or radiation treatments.
Eligibility
Inclusion Criteria4
- Previously cryopreserved ovarian tissue
- Ovarian insufficiency and/or candidate for pregnancy
- Good health
- Oncologist's clearance
Exclusion Criteria6
- Patients considered to be high risk for surgical complications
- Women with contraindication for pregnancy if goal is to achieve pregnancy
- Women positive for the BRCA mutations
- Women with a history of leukemia, ovarian cancer or a cancer that likely involved ovaries at the time of ovarian tissue collection
- Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
- Current pregnancy
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Interventions
Pieces of previously frozen ovarian cortex will be put in the abdomen laparoscopically, or with mini laparotomy
Locations(1)
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NCT03496636