RecruitingNot ApplicableNCT07394530

Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS

A Comparative Study of In Vitro Fertilization Outcomes Between PPOS and Antagonist Protocols in Women With Polycystic Ovary Syndrome


Sponsor

Hanoi General Hospital (Vietnam)

Enrollment

400 participants

Start Date

Jan 20, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This trial is comparing two different hormone stimulation protocols — PPOS (progestin-primed ovarian stimulation) versus the standard antagonist protocol — to see which leads to better IVF outcomes in women with polycystic ovary syndrome (PCOS). PCOS affects ovulation and is a common cause of infertility. **You may be eligible if...** - You are a woman aged 18 to 40 - You have been diagnosed with PCOS using the Rotterdam criteria (irregular periods, elevated androgen levels, and/or polycystic ovaries on ultrasound) - You are scheduled for IVF treatment, either due to PCOS alone or combined with other infertility factors - Your partner has normal or mildly abnormal sperm **You may NOT be eligible if...** - You have uterine abnormalities (such as fibroids distorting the cavity or congenital malformations) - You have a history of ovarian surgery - You have poor ovarian reserve - You have had previous IVF cycles that resulted in poor response - You have other serious health conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGProgestin-Primed Ovarian Stimulation (PPOS)

Ovarian stimulation using a progestin-primed ovarian stimulation (PPOS) protocol, including gonadotropins combined with oral progestin for pituitary suppression during in vitro fertilization treatment.

DRUGGnRH Antagonist Protocol

Ovarian stimulation using a gonadotropin-releasing hormone (GnRH) antagonist protocol for pituitary suppression during in vitro fertilization treatment.


Locations(1)

Hanoi General Hospital

Hanoi, Hanoi, Vietnam

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NCT07394530


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