Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

This trial is studying whether adding a drug called epacadostat (which helps the immune system fight cancer) to the standard pre-surgery chemoradiation treatment for locally advanced rectal cancer can improve outcomes. **You may be eligible if...** - You have been recently diagnosed with locally advanced rectal cancer (stage 2 or 3, or stage 1 not suitable for sphincter-sparing surgery) - You are planning to receive short-course radiation therapy before surgery - You are 18 years or older and in reasonably good health (ECOG score 0–2) - Your blood counts, liver, and kidney function are within acceptable ranges - You are using contraception if you could become pregnant or father a child **You may NOT be eligible if...** - You have not been newly diagnosed (prior chemotherapy for rectal cancer disqualifies you) - You are pregnant or planning to become pregnant - Your organ function is outside the required thresholds - You are unable to understand or sign a consent form Talk to your doctor to see if this trial is right for you.